CCC 4+ with 4 or 8xAA everything else on very high/ultra high, whatever completely saturates 1Gb vram in MWLL at 1920x1080
Max settings 1920x1200, 8xaa fills, 16xaf.
It doesn't even take that much to fill over 1gb.
But we are talking triple screen, triplescreen, max settings 5760x1200 8xaa, 16xAF and I use 1.5gb-1.7gb Vram (depends on the map) quite easily. If I had only the stock GTX580X2, I wouldn be able to play on those settings just about but lets not talk about other games like metro which somehow managed to use 2.5gb of Vram....Times like this I'm like wooot thank God I brought the 3gb vram version.
On a single screen 1gb is enough, unless you are going near top end, but it's unlikly your find a near top end card with only 1gb of Vram. Multiscreen badly needs 2gb per GPU, unless the GPU are not strong enough to raise the settings to a standard where the settings are high enough to use all that Vram.
Oh and AA doesn't destroy my FPS at all. Just lowers it by a couple of fps...Vram ftw.