I don't really think there's much left to say about the room really, it (alongside other "so bad it's good" movies such as birdemic) has become a cultural phenominum outside of what the movies are really worth. I mean even to this day the prince Charles cinema in London does a monthly screening of it, which as you'd expect descends into madness and people shouting at the movie/throwing spoons etc.
I'll happily go over "The disaster artist" when it comes out though, as Hollywood's love story with Wiseau is kinda more interesting to me at this point.
As for the man himself? Well it's obvious he's self deluded, but hes obviously not stupid. He's managed to ride this thing pretty well. I watched his second movie (the house that screamed Alex? I can't remember the name) and his self awareness ruined it really.
I personally would like to give him a budget (one not funded by his rumoured arms dealing past) and give him carte blanche to do what ever he liked without the pressure of expectations or the thought of having living up to anything. I almost see him as a prototype John Walters (though without the LGBT angle), in so much that his filming style is very slap dash (through inexperience and over confidence), filming on two totally different types of film is a good example of it.
As for the Science Fiction books. Well firstly cheers for the complement, secondly it would be something I'd happily consider doing, the problem would be how to keep it visual stimulating whilst I rambled on. I can't really do any on location filming or anything as I lack the equipment (camera, lighting, sound).
But I'll happily give it a shot, since it was your idea what book would you like to start with?