You guys should also always remember to check your "IRQ's" for conflicts. ie.. Make sure that you do not have any high-load items sharing the the same IRQ.
By this I mean, you don't want your video cards, sound or ethernet controllers sharing the same IRQ. If these items do this. You will bottleneck even a top of the line system in a heartbeat.
For those who do not know.. and for me to not have to go into "big language explanation".. an IRQ is an interrupt request. What is that you ask? In a nutshell, it controls the flow of data in your computer. If two high load items are on the same IRQ. Data gets backed up and the system suffers and each tries to take priority over the other.
Granted, it is a bit more complex than how I have described it, but the meaning is the same. Don't have two high load items on the same IRQ or you will have performance issues, no matter how "top of the line" a machine you have is.